a brief review of chelators for radiolabeling oligomers简要回顾放射性标记的寡聚物的螯合剂.pdfVIP

Materials 2010, 3, 3204-3217; doi:10.3390/ma3053204 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Review A Brief Review of Chelators for Radiolabeling Oligomers Yuxia Liu, Guozheng Liu * and Donald J. Hnatowich Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA; E-Mails: yuxia.liu@ (Y.L.); donald.hnatowich@ (D.J.H.) * Author to whom correspondence should be addressed; E-Mail: guozheng.liu@; Tel: +1-508-856-1958; Fax: +1-508-856-6363. Received: 13 March 2010; in revised version: 26 March 2010 / Accepted: 10 May 2010 / Published: 14 May 2010 Abstract: The chemical modification of oligomers such as DNA, PNA, MORF, LNA to attach radionuclides for nuclear imaging and radiotherapy applications has become a field rich in innovation as older methods are improved and new methods are introduced. This review intends to provide a brief overview of several chelators currently in use for the labeling of oligomers with metallic radionuclides such as 99mTc, 111In and 188Re. While DNA and its analogs have been radiolabeled with important radionuclides of nonmetals such as 32P, 35S, 14C, 18F and 125I, the labeling methods for these isotopes involve covalent chemistry that is quite distinct from the coordinate-covalent chelation chemistry described herein. In this review, we provide a summary of the several chelators that have been covalently conjugated to ol