9-methyl-3,5-dioxo-4-azatricyclo[5.2.2.02,6]undec-8-ene-1,8-diyl diacetate9-methyl-3,5-dioxo-4-azatricyclo[5.2.2.02 6]undec-8-ene-1 8-diyl二醋酸盐.pdfVIP

Molbank 2010, M685; doi: 10.3390/M685 OPEN ACCESS molbank ISSN 1422-8599 /journal/molbank Short Note 9-Methyl-3,5-dioxo-4-azatricyclo[2,6]undec-8-ene-1,8-diyl Diacetate Anna Bielenica * and Jerzy Kossakowski Chair and Department of Medical Chemistry, 1st Faculty of Medicine, Medical University of Warsaw, 3 Oczki Street, 02-007 Warsaw, Poland * Author to whom correspondence should be addressed; E-Mail: abielenica@.pl. Received: 5 May 2010 / Accepted: 20 May 2010 / Published: 25 May 2010 Abstract: 9-Methyl-3,5-dioxo-4-azatricyclo[2,6]undec-8-ene-1,8-diyl diacetate was synthesized from 2-methylcyclohexane-1,3-dione and 1H-pyrrole-2,5-dione. The title compound was characterized by 1H NMR, 13C NMR, elemental analysis and MS. Keywords: cyclic imide; 4-azatricyclo[2,6]undecene 1. Introduction Cyclic imides are extensively used as analgesic [1] and antinociceptive agents [2], or as reactants for polymer synthesis [3]. An imide nucleus can be also found in a structure of anxiolytic [4], antimicrobial [5], anticancer and anti-inflammatory substances [6,7]. They are also the objects of quantum chemical studies [8]. Several techniques to produce cyclic imides were described. Thus, unsubstituted cyclic anhydrides are successfully subjected to the reaction with ammonia, urea, formamide, lithium nitride or ammonium carbonate under mild conditions [9– 11]. Substituted polycyclic imide rings are usually prepared in the Diels-Alder reaction [1