9g4 autoreactivity is increased in hiv-infected patients and correlates with hiv broadly neutralizing serum activity9 g4 autoreactivity增加艾滋病病毒感染者和艾滋病广泛中和血清相关活动.pdfVIP

9g4 autoreactivity is increased in hiv-infected patients and correlates with hiv broadly neutralizing serum activity9 g4 autoreactivity增加艾滋病病毒感染者和艾滋病广泛中和血清相关活动.pdf

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9g4 autoreactivity is increased in hiv-infected patients and correlates with hiv broadly neutralizing serum activity9 g4 autoreactivity增加艾滋病病毒感染者和艾滋病广泛中和血清相关活动

9G4 Autoreactivity Is Increased in HIV-Infected Patients and Correlates with HIV Broadly Neutralizing Serum Activity 1 2 1 1 2 2 James J. Kobie *, Danielle C. Alcena , Bo Zheng , Peter Bryk , Jonelle L. Mattiacio , Matthew Brewer , 3 4 2 3 1 Celia LaBranche , Faith M. Young , Stephen Dewhurst , David C. Montefiori , Alexander F. Rosenberg , 5 6 6 1 Changyong Feng , Xia Jin , Michael C. Keefer , Ignacio Sanz 1 Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, United States of America, 2 Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America, 3 Department of Surgery, Laboratory for AIDS Vaccine Research and Development, Duke University Medical Center, Durham, North Carolina, United States of America, 4 J.P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, United States of America, 5 Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York, United States of America, 6 Division of Infectious Disease, University of Rochester Medical Center, Rochester, New York, United States of America Abstract The induction of a broadly neutralizing antibody (BNAb) response against HIV-1 would be a desirable feature of a protective vaccine. Vaccine strategies thus far have failed to elicit broadly neutralizing antibody responses; however a minority of HIV- infected patients

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