中药小儿定喘方治疗儿童哮喘临床疗效评价.docVIP

中药小儿定喘方治疗儿童哮喘临床疗效评价[摘要] 目的:评价中药小儿定喘方治疗儿童哮喘的临床疗效,为进一步阐述其药理机制提供临床佐证。方法:40例临床诊断为儿童哮喘的患儿随机分成两组,每组各20例,治疗组选用中药小儿定喘方治疗,对照组不用中药方治疗,两组哮喘儿童的常规治疗相同,疗程为1个月。观察疗效及药物的不良反应。结果:中药小儿定喘方治疗组治愈12例,显效6例,无效2例,有效率为90%;对照组治愈5例,显效6例,无效9例,有效率为55%。两组资料用确切概率法统计学检验,P=0.031,差异有统计学意义。在治疗过程中未发现有明显的毒副作用。结论:中药小儿定喘方治疗儿童哮喘的临床疗效肯定且安全,它为儿童哮喘的临床治疗提供了有用可靠的中医途径。 [关键词] 小儿定喘方;儿童哮喘;疗效评价 [中图分类号] R725.6 [文献标识码]B [文章编号]1674-4721(2010)04(b)-081-02 The evaluation of clinical curative effect of the traditional Chinese medicine Xiaoerdingchuan formula to treat children?s asthma HUANG Jianjun, ZHAO Chunling, TONG Zhijie, LIN Lijing, ZHAO Mingqi, MIAO Xiangyi, YU Le, ZHOU Jun (Guangzhou Children’s Hospital, Guangzhou 510120, China) [Abstract] Objective: To evaluate the clinical therapeutic effect of the Chinese traditional medicine Xiaoerdingchuan formula to treat children’s asthma. Methods: 40 cases of asthmatic children were divided into 2 groups randomly, each group with 20 cases, the therapy group being used the traditional medicine formula, while the control group having the same treatments with the therapy group except the traditional medicine formula, the whole treatment course for one month. The two groups were observed efficacy and adverse drug reactions. Results: The therapy group with Chinese traditional medicine Xiaoerdingchuan formula, there were 12 cases of cure, 6 cases of excellence and 2 case of inefficiency respectively; the effective power ratebeing was 90%, while there were 5 cases of cure in the control group, 6 cases of excellence and 9 cases of inefficiency respectively; the effective power ratewas 55%. The difference between the two groups was significant, P 中医是中国的国粹和国宝,中医治疗哮喘有着数千年的历史,有其独特的理论体系和独到的临床功效。从中医的角度看,根据辨证施治可将哮喘分为寒邪伏肺型、气郁痰阻型、痰瘀气壅型、肺肾两虚型等,不同类型的哮喘其病机不同,用药不同,疗效自然不一样。中国中医百家争鸣,不同中医名家根据自己行医经验总结出独特的医方,自成体系,但其临床疗效是确切的。目前已有研究提示中药方剂在治疗哮喘中的作用机制主要是调节机体免疫功能、改善气道通畅、提高机体整体自稳态等[6-7]。 中药小儿定喘方是本院中医独创的专治儿童哮喘的中药方,已在临床应用20余年,取得较好的临床效果。本方由三拗汤和三子养亲汤加皂荚、地龙、僵蚕而成。三拗汤原出于《和剂局方》,方中麻