Clotting factors on the application in liver diseases（凝血因子在肝脏疾病中的应用）.doc

Clotting factors on the application in liver diseases [Abstract] prothrombin time (prothrombintime, PT) is a reflection of hepatic synthetic function, reserve function, disease severity and prognosis of a very important indicator. Coagulation factor Ⅷ not only produced by the liver cells, but also by sinusoidal endothelial cells and Koop Eph cells, other tissues such as the kidney can produce when liver cells to synthesize dysfunction, sinusoidal endothelial cells and Kupffer cells remained factor Ⅷ synthesis, hepatic clearance dysfunction, endotoxin and immune factors to stimulate make it increase the synthesis and release, but liver disease with DIC that due to large consumption of clotting factors, so that reduced levels of coagulation factor Ⅷ activity, so China will coagulation factor Ⅷ activity of less than 50% of normal liver cirrhosis diagnosis of DIC as one of the prerequisites. [Keywords:] liver clotting factor Current clinical detection of coagulation factors has become a reality, it is judged liver disease than the PT, will provide earlier and more accurate information. 1 PT clinical application in liver disease laboratory reports PT 4 ways: second, activity (prothrombintime, activity percentage, PTA), rate (prothrombintimeratio, PTR), international normalized ratio (internationalnormalizedratio, INR) .4 forms in different clinical application value. 1.1 PT application value in liver disease mainly synthesized by the liver PT clotting factors I, Ⅱ, Ⅴ, Ⅶ, Ⅹ level decision, it is particularly important role in liver disease with acute hepatitis PT abnormality rate of 10% to 15%, Chronic hepatitis, 15% to 51%, 71% cirrhosis, fulminant hepatitis was 90% in 2000 diagnostic criteria for viral hepatitis, PTA is viral hepatitis clinical staging one of the indicators. mild chronic viral hepatitis PTAgt; 70%, moderate 70% to 60%, severe 60% to 40%; liver cirrhosis PTAgt; 60%, decompensated PTA lt;60%, severe hepatitis PTA lt;40%. Child-Pug