Chronic HBV infection serum HBV-DNA content of the liver pathology correlation analysis（慢性乙型肝炎病毒感染血清病毒dna肝脏病理学相关分析的内容）.doc

Chronic HBV infection serum HBV-DNA content of the liver pathology correlation analysis Abstract: Objective To investigate the relationship between chronic HBV infection, serum HBV-DNA content and liver histopathology analysis comparing 259 cases of chronic HBV infection, serum HBV-DNA content of liver fibrosis and the degree of inflammation results HBeAg-positive chronic HBV infection, the severity of the liver and serum HBV-DNA quantitative level is not relevant (pgt; 0.05, HBeAg-negative patients significantly correlated (p lt;0.05. immunohistochemical staining HBcAg cytoplasm positive HBV-DNA content Conclusions chronic HBV serum HBV-DNA content in a certain extent, reflect the degree of liver inflammation and fibrosis, HBV-DNA content in 98% of the positive staining rate of 107 copy number of pulp to hepatitis B patients, especially those with normal liver function antiviral therapy of infection by providing a reliable basis. Keywords: HBV-DNA content of liver pathology, chronic HBV infected Hepatitis B is a global infectious disease caused by the hepatitis B virus, nationwide hepatitis B serum epidemiological investigation showed that 9.09% of the HBsAg prevalence rate in the general population in China in 2002, it is estimated that about 120 million people with chronic HBV infection [1] of HBV not cause significant damage to the liver tissue, the body’s immune response, especially lymphocytes cleared HBV-DNA damage liver cells before the inflammatory process, there is a certain relationship between serum HBV-DNA content in the liver tissue lesions. explore this problem, we will Kunming hospital for infectious diseases from January 2007 to December 2010, liver biopsy of chronic HBV infection, serum HBV-DNA content were analyzed, are as follows. 1 objects and methods 1.1 Case selection Kunming hospital for infectious diseases, liver biopsy of chronic HBV infection, 259 cases from January 2007 to December 2010, 174 cases were male, female 85 ca