Cholesterol and high-sensitivity C-reactive protein in acute coronary syndrome patients with early Simvastatin（胆固醇和高敏c反应蛋白在急性冠脉综合征患者早期辛伐他汀）.doc

Cholesterol and high-sensitivity C-reactive protein in acute coronary syndrome patients with early Simvastatin [Keywords] acute coronary syndrome [Abstract] Objective To observe the acute coronary syndrome (ACS patients with early simvastatin therapy on serum high-sensitivity C-reactive protein (hsCRP and lipid levels to explore the role of statins in ACS early intervention. Methods hospitalized patients with ACS 80 cases, a randomized, single-blind, controlled method ACS were divided into a control group (n = 38, the daily oral placebo and simvastatin treatment group (n = 42, simvastatin 20 mg / d, the onset of 48 h within start taking), the same two groups of other treatments, observed for four weeks, the concentration of serum hs-CRP and lipids were measured before and after treatment. hsCRP concentration using enzyme-linked immunosorbent assay, lipids using enzymatic 4 weeks of treatment results simvastatin group compared with the control group, serum hsCRP and total cholesterol (TC, triglycerides (TG and low-density lipoprotein cholesterol (LDLC) concentration was significantly lower (P lt;001, while the control group before and after treatment showed no significant (all Pgt; 0.05) Conclusion ACS patients early simvastatin therapy can significantly improve blood lipids, reduce hsCRP levels. simvastatin to decrease inflammation and plaque stabilization. [Keywords] acute coronary syndrome, C-reactive protein, lipids, simvastatin [Abstract] Objective to observe the effect of simvastatin on serum lipids and high sensitive Creactive protein (hsCRP) at the early stage in patients with acute coronary syndrome (ACS). Methods 80 hospitalized patients with ACS were selected and were randomly divided into control group (with placebo for 4 weeks, n = 38) and simvastatin group (with simvastatin 20mg per day, n = 42). Simvastatin and placebo were used within 48 hours from onset, and there were no other different therapeutic methods between two groups. The conce