Changes on the blood system in hypertensive disease L arginine carrier transporter dynamics(变化在高血压血液系统疾病L精氨酸载体转运体动力学).doc
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Changes on the blood system in hypertensive disease L arginine carrier transporter dynamics(变化在高血压血液系统疾病L精氨酸载体转运体动力学)
Changes on the blood system in hypertensive disease L arginine carrier transporter dynamics
Author: Wang Xu Hongtao Yao Xinghai ZANG Yi-min Chaoshu
[Keywords] hypertension Keywords: hypertension; erythrocytes; platelet; L-arginine
Abstract: Objective To investigate the human blood system essential hypertension (EH L-arginine (L-Arginine, L-Arg carrier transporter function changes. Methods EH 12 patients and healthy adults 16 cases, extraction of platelets (Pt and red blood cell (RBC Pt and RBC dynamics of L-Arg transport characteristics were measured. Results the EH patients Pt and RBC was 3 HL-Arg transporter high affinity carrier transit mode, 3 HL EH patients at different concentrations -Arg transport rate is significantly lower than the control group (P lt;0.01.Eadie-Hofstee Plot analysis, the largest transporters rate of EH patients Pt L-Arg (V
max for the control group, 79% (P lt;0.05, Pt3 HL-Arg transporter Michaelis constant value (Km no significant difference between L-Arg transport capacity of RBC Y + the carrier transit system’s transport capacity was significantly lower than the normal group ( P lt;0.01, while the Y-+ L carrier transit system of transit capacity without significantly changing the L-Arg total transshipment of the maximum rate of Y-+ carrier transit system’s maximum rate, respectively, compared with the control group, reducing by 36.8% and 42.5% (P lt;0.01, each group Km was no significant difference between the conclusions of EH patients Pt and RBC L-Arg the carrier transit system obvious exception.
Keywords: hypertension; erythrocyte; platelet; L-arginine
Abstract: AIM To investigate the changes of L-arginine
(L-Argtransportation kinetic characteristics in erythrocytes (RBC) and platelets (ptof patients with essential hyperten-sion (EH.METHODS 12EH patients were studied with16normotensive people as control.The RBC and Pt were prepared and the transportation of L-Arg was measured by using the method described by Ghi
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