Changes on different brain regions of ovariectomized rats expression of tyrosine kinase A（变化在不同的大脑区域大鼠去卵巢后的骨骼状况酪氨酸激酶的表达）.doc

Changes on different brain regions of ovariectomized rats expression of tyrosine kinase A Author: Frank Tao, Yang Xuewei Zong-Jun Guo Jin Liying Du Fang [Keywords:] ovarian [Abstract] Objective To observe the brain of ovariectomized rats in different parts of the tyrosine kinase A (change of TrkA expression. Singh method to establish a rat ovariectomy model (OVX group, the immunocytochemical staining observed in hippocampal CA1 region, cortex amygdaloid complex area, basal forebrain TrkA positive cells of the brain Meynert nucleus and other parts of the expression changes. the results of the control rats of each observation area there are a large number of TrkA expression, compared with the control group, OVX group brain hippocampal CA1 region, cerebral cortex, almonds TrkA positive cell number of complex areas decreased significantly (t = 5.90 ~ 8.57, P lt;0.01) of Meynert nucleus, no significant difference (t = 1.65, Pgt; 0.05. conclusion rat estrogen decline may be caused by brain parts TrkA expression was decreased, estrogen and growth factor receptor systems may exist a relationship of mutual influence. [Keywords:] tyrosine kinase A, estrogen, rats, Wistar [ABSTRACT] ObjectiveTo observe the changes of tyrosine kinase A (TrkA) in different cerebral regions of ovariectomized rats. MethodsAdult healthy female Wistar rats were randomly divided into two groups: model group (OVX group) and control group. The positive expressions of TrkA cells in the hippocammpi CA1, cortex, amygdala, Meynert of the basal forebrain were compared between the two groups.ResultsThe positive TrkA cells were observed in every section of the brain in control group, while in model group, the positive TrkA cells in the hippocammpi CA1 , cortex and amygdala were distinctly decreased as compared with the control group (t = 5.90-8.57, P lt;0.01. No difference was found in the Meynert nucleus between the two groups. Conclusion The low estrogen induces decrease of positive expressi