胃粘膜肠上皮化生的反重演律假说（Hypothesis of reverse repeat law of intestinal metaplasia in gastric mucosa）.docVIP

胃粘膜肠上皮化生的反重演律假说（Hypothesis of reverse repeat law of intestinal metaplasia in gastric mucosa） Hypothesis of reverse repeat law of intestinal metaplasia in gastric mucosa Chen XY Recapitulation law is the law that repeats the phylogeny of biological individuals during embryo development [1]. This rule is also applicable to the regeneration and repair process of tissue [2]. The intestinal metaplasia of gastric mucosa is the central point of pathological changes of gastric mucosa and has a close relationship with the prognosis of gastric disease. A lot of research on intestinal metaplasia of the gastric mucosa and most concentrated on their tissue of origin, identification and prognostic significance, but the biological nature of intestinal metaplasia is less studied, it is generally believed that only a non-specific adaptation [3 ~ 6]. We think this understanding is too simple to explain the multiple specific biological phenomena of intestinal metaplasia. The hypothesis presented in this paper is that intestinal metaplasia is not simply a replacement of one digestive epithelium with another, but a de differentiation process, which is the evolution of the gastric mucosal reverse regularity. I. evolution of the stomach and intestine 1. from the point of organ development, the intestine develops earlier than the stomach. In chemistry, the stomach began to appear in the fish, is swallowing large pieces of food required [7]; the cell breathing function structure such as low [any animal stomach] 8 mesh like sheath; embryologically ranged from 13 weeks to 14 weeks of embryo Weicai finally form [9]; fetal intestinal and gastric mucosa two kinds of gastric intestinal epithelial antigen antigen, until several months after birth, after left gastric epithelial antigen [10]. Duodenal and ileal epithelial membrane antigen (EMA) were positive, EMA negative colon epithelial tumor cells, high differentiation EMA exists in normal human epithelial cells and epithelial in origin, differen