糠酸莫米松（Mometasone furoate）.docVIP

糠酸莫米松（Mometasone furoate） Mometasone furoate [name of drug] Chinese common name: mometasone furoate English generic name: Mometasone Furoate Other names: Aloson, Ai Rongsong, mometasone furoate, Martha Momison, Mo pine, nasonex, bran, pine, Eloson, Fu lausson Eloson, Mometasone, Mometasonum, Nasonex [clinical application] 1. nasal sprays for the prevention and treatment of seasonal or perennial allergic rhinitis. * (6). 2. nasal sprays for the treatment of nasal polyps. * (13). 3., soft cream (milk) cream for external application of glucocorticoid is effective in the treatment of skin disease, (1) - such as contact dermatitis, atopic dermatitis, seborrheic dermatitis, eczema, neurodermatitis, psoriasis, lichen planus, discoid lupus erythematosus. (9) the itching and etc. non infectious inflammatory skin disease. * (1). 4. oral dry powder inhaler for preventive treatment of asthma. * (13). [pharmacology] 1. pharmacodynamics, this medicine is the synthesis of medium and powerful topical glucocorticoid, and its dose of local anti-inflammatory action will not lead to systemic action. * (11) the drug through the skin (or nasal absorption), combined with glucocorticoid receptor protein in the cytoplasm, exert strong anti-inflammatory, anti allergic, vasoconstriction, reducing vascular permeability, reduce leakage, inhibition of cell division and antipruritic effect. The drug has an increased strength and a disproportionate increase in adverse effects. * (9) the foreign data suggest that, compared with other topical corticosteroids, the medicine has high curative effect, and is not easy to cause the skin (or nasal mucosa) adverse reactions or atrophy of adrenal suppression. * (5). 2. 、 after topical administration of topical drugs, the onset time was 3 to 3 weeks, and the skin absorption rate was about 0.4%-0.7%. Intranasal administration, in the first 12 hours after onset (6) * * can, after nasal spray in plasma with undetectable drug concentration. Local skin (or nasal s