第20章 解热镇痛抗炎药（The twentieth chapter is antipyretic, analgesic and anti-inflammatory drugs）.docVIP

第20章 解热镇痛抗炎药（The twentieth chapter is antipyretic, analgesic and anti-inflammatory drugs） The twentieth chapter is antipyretic, analgesic and anti-inflammatory drugs Basic Requirements Key and difficult points Teaching hours Synopsis 1 basic requirements [TOP] 1.1 master the combined action and principle of antipyretic, analgesic and anti-inflammatory drugs. The characteristics, uses and common adverse reactions of aspirin. 1.2 、 familiar with the classification of antipyretic, analgesic and anti-inflammatory drugs and all kinds of representative drugs. 1.3 to understand the characteristics, uses and adverse reactions of other types of antipyretic, analgesic and anti-inflammatory drugs. 2 key and difficult [TOP] 2.1 key The concept, classification, mechanism, characteristics, clinical application, adverse reactions, absorption and metabolism characteristics of acetylsalicylic acid, clinical use, common adverse reactions and preventive measures. 2.2 difficulties The mechanism, characteristics, clinical application and adverse reactions of antipyretic analgesics. Discovery and function of cyclooxygenase isozyme COX2. 3 teaching hours [TOP] Recommendation 4 hours. 4 Summary [TOP] 4.1 pharmacological actions, mechanisms of action and common adverse reactions of antipyretic analgesics 4.1.1 pharmacological action (I) antipyretic effect 1. only the high body temperature dropped to normal, no effect on normal body temperature. 2., only affect the heat dissipation process, without affecting the heat production process. 3., the antipyretic mechanism is to inhibit the hypothalamic temperature and regulate the activity of central oxygenase (prostaglandin synthetase), thereby inhibiting the synthesis of prostaglandin (PG). (two) analgesic effect 1., non narcotic (non addictive) analgesics, without euphoria, tolerability, and respiratory depression. 2., the intensity of pain is weaker than pethidine, which is effective for chronic blunt pain, and is not effective for traumatic