第3节细胞的衰老和凋亡（Third cell senescence and apoptosis）.docVIP

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第3节细胞的衰老和凋亡（Third cell senescence and apoptosis）.doc

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第3节细胞的衰老和凋亡（Third cell senescence and apoptosis）

第3节细胞的衰老和凋亡（Third cell senescence and apoptosis） Third cell senescence and apoptosis Learning goal Knowledge aspect: 1. talk about the relationship between individual aging and cell senescence. 2. describe the characteristics and causes of cell senescence. 3. know the meaning of apoptosis and the difference between it and cell necrosis. Emotions, attitudes, and values: To investigate the relationship between cell senescence and apoptosis and human health, and to pay attention to the living conditions of the elderly. Ability aspect: Data collection and Analysis on issues related to social aging. Total content solution Cell senescence and death is a common life phenomenon and the basic law of cell life. First, the relationship between individual aging and cell aging Cell aging or death is the aging or dying of individuals; multicellular organisms, cells in the body are constantly renewing. That is to say, cells of a multicellular organism are dying and dying at all times, and new cells are added to supplement them. Therefore, cell senescence and death in multicellular organisms is not the same as individual aging death. Two. Characteristics of cell senescence Cell senescence is a physiological and biochemical process in cells, and changes in morphology, structure and function of senescent cells are obvious. Morphological changes: because of reduced intracellular water, the cell shrinks and the volume shrinks. Changes in structure: enlargement of nucleus volume, pyknosis of chromosome, increase of lysosome number and volume, and disorder of endoplasmic reticulum. Functional changes: because of the decrease of the number of mitochondria, the respiration rate slows down; some enzymes decrease in activity and the rate of protein synthesis decreases. Such as: human hair is white because of human hair base melanocytes aging, cell tyrosinase activity decreased, resulting in the synthesis of melanin blocked. Because of the change of cell membrane permeability, the transport