瑞芬（SVECOFENNIAN）.docVIP

瑞芬（SVECOFENNIAN） [name of drug] remifentanil [English name] Remifentanil [alias] regant RUIMI; remifentanil; fentanyl; remifentanil hydrochloride; RemifentanilHydrochloride; Ultiva [Formula] remifentanil powder injection: 1mg/ branch, 2mg/ branch, 5mg/ branch. [pharmacology] this product is an analgesic drug and is highly potent in the metabolism of nonspecific blood and tissue esterases, Ultrashort acting opioid receptor agonist. Selectively acting on the mu receptor, exhibiting a typical opioid like pharmacological activity Effects include analgesia, respiratory depression, sedation, muscle tone enhancement, and bradycardia. The action is characterized by onset of action Rapid and rapid disappearance, independent of dose and time, and opioid action does not require reversal of the drug. It can Period of adverse reactions such as respiratory depression caused many recovery to overcome fentanyl and alfentanil after operation. book The relative potency of fentanyl 50 ~ 100 times, 20 ~ 50 times of alfentanil. [pharmacokinetics] the maximum effective time of analgesia is 1 ~ 3min. Single intravenous administration of analgesics Continue 3 ~ 10min. The binding rate of plasma protein was 92%, the distribution half-life was 1min, and the distribution volume was 30 ~ 60L. This product is quickly transported by esterase in blood and tissues, and the metabolite is inactive. Total body clearance rate was 40 ~ 60ml/ (kg. Min), no accumulation in vivo. 90% discharged by the kidneys, can the milk secretion is unclear Chu. The elimination half-life of the parent compound ranged from 3 to 10min. Used for analgesia during operation and after operation; used as an anaesthetic adjuvant. [contraindications] 1. are allergic to this or other fentanyl derivatives. 2. patients with myasthenia gravis prohibited Use. 3. patients with bronchial asthma are forbidden. Children under 4.2 years of age do not have clinical medication, so they are not recommended Use。 5., this product can pass the