Speckle variance optical coherence tomography （斑纹方差光学相干断层扫描）.pdfVIP

Speckle variance optical coherence tomography for imaging microcirculation ¨ D. Klawitter, D. Hillmann, M. Pieper, P. Steven, J. Wenzel, and G. Huttmann Abstract—Non-invasive flow detection and in-vivo measure- first type, as phase-resolved Doppler imaging, measure phase ment are one of the most requested clinical applications for shifts evoked by moving scatterers in the observed tissue. medical imaging modalities to investigate vascular pathologies The second type including speckle contrast (sc) and speckle and responsiveness to drug therapy. Implementing speckle vari- ance calculation visualization in a market-proven optical variance (sv), respectively, use speckle fluctuations to identify coherence tomography (OCT) system we demonstrate an an- microvasculature by calculating either the interframe contrast giography imaging algorithm that provides angle independent, or the intensity variance of structural images [3]. depth-resolved flow measurement up to a capillary scale. The To understand interframe speckle fluctuations a short review feasibility of quantitative flow analysis with speckle variance OCT of laser speckle and its properties is presented. The advent of (svOCT) is to be demonstrated by the evaluation with silicone phantom, animal and human probes, respectively. First results laser speckle theory is dated to the invention of laser in the lead to the assumption that reliable access to quantified flow 1960’s. When laser light illuminates an irregular surface, the velocities with svOCT is not obtainable. However svOCT delivers high coherence of t