neonatal colonisation expands a specific intestinal antigen-presenting cell subset prior to cd4 t-cell expansion, without altering t-cell repertoire新生儿殖民扩展特定的肠道抗原呈递细胞子集cd4 t细胞扩张之前,在不改变t细胞.pdfVIP

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neonatal colonisation expands a specific intestinal antigen-presenting cell subset prior to cd4 t-cell expansion, without altering t-cell repertoire新生儿殖民扩展特定的肠道抗原呈递细胞子集cd4 t细胞扩张之前,在不改变t细胞.pdf

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neonatal colonisation expands a specific intestinal antigen-presenting cell subset prior to cd4 t-cell expansion, without altering t-cell repertoire新生儿殖民扩展特定的肠道抗原呈递细胞子集cd4 t细胞扩张之前,在不改变t细胞

Neonatal Colonisation Expands a Specific Intestinal Antigen-Presenting Cell Subset Prior to CD4 T-Cell Expansion, without Altering T-Cell Repertoire 1 .¤a 1. 1 1 1 Charlotte F. Inman * , Georgina M. Laycock , Louisa Mitchard , Ross Harley , James Warwick , Rachel Burt1, Pauline M. van Diemen2¤b, Mark Stevens2¤c, Mick Bailey1 1 School of Clinical Veterinary Science, University of Bristol, Langford, Bristol, United Kingdom, 2 Institute for Animal Health, Compton, Newbury, Berkshire, United Kingdom Abstract Interactions between the early-life colonising intestinal microbiota and the developing immune system are critical in determining the nature of immune responses in later life. Studies in neonatal animals in which this interaction can be examined are central to understanding the mechanisms by which the microbiota impacts on immune development and to developing therapies based on manipulation of the microbiome. The inbred piglet model represents a system that is comparable to human neonates and allows for control of the impact of maternal factors. Here we show that colonisation with a defined microbiota produces expansion of mucosal plasma cells and of T-lymphocytes without altering the repertoire of alpha beta T-cells in the intestine. Importantly, this is preceded by microbially-induced expansion of a signal regulatory protein a-positive (SIRPa+) antigen-presenting cell subset, whilst SIRPa2CD11R1+ antigen-presenting cells (APCs) are unaffected by colonisation. The central role of intestinal APCs in the induction and maintenance of mucosal immunity implicates SIRPa+ antigen-presenting cells as or