nest making and oxytocin comparably promote wound healing in isolation reared rats巢制造和后叶催产素同样促进隔离饲养大鼠伤口愈合.pdfVIP

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nest making and oxytocin comparably promote wound healing in isolation reared rats巢制造和后叶催产素同样促进隔离饲养大鼠伤口愈合.pdf

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nest making and oxytocin comparably promote wound healing in isolation reared rats巢制造和后叶催产素同样促进隔离饲养大鼠伤口愈合

Nest Making and Oxytocin Comparably Promote Wound Healing in Isolation Reared Rats Antonia Vitalo2,4,5,6, Jonathan Fricchione2,4,5,6, Monica Casali2,4,5,6,8, Yevgeny Berdichevsky2,5,6,8, Elizabeth A. Hoge1,7, Scott L. Rauch7,10, Francois Berthiaume2,5,6,8, Martin L. Yarmush2,5,6,8, Herbert Benson3,4,9, Gregory L. Fricchione 1,4,7*, John B. Levine1,2,4,5,6,7* 1 Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, United States of America, 2 Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America, 3 Department of Medicine Services, Massachusetts General Hospital, Boston, Massachusetts, United States of America, 4 Benson Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, 5 Center for Engineering and Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, 6 Shriners Burns Hospital, Boston, Massachusetts, United States of America, 7 Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America, 8 Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America, 9 Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, 10 McLean Hospital, Belmont, Massachusetts, United States of America Abstract Background: Environmental enrichment (EE) fosters attachment behavior through its effect on brain oxytocin levels in the hippocampus and other brain regions, which in turn modulate the hypothalamic-pituitary axis (HPA). Social isolation and other stressors negatively impact physical healing through their effect on the HPA. Therefore, we reasoned that: 1) provision of a rat EE (nest building with NestletsH) would improve wound healing in rats undergoing stress due to isolation rearing and 2) that ox