mucosal leishmaniasis caused by leishmania (viannia) braziliensis and leishmania (viannia) guyanensis in the brazilian amazon粘膜利什曼病由利什曼虫(viannia)braziliensis和利什曼虫(viannia)guyanensis在巴西亚马逊河.pdfVIP

Mucosal Leishmaniasis Caused by Leishmania (Viannia) braziliensis and Leishmania (Viannia) guyanensis in the Brazilian Amazon 1,2 2 1,3 ˆ Jorge Augusto de Oliveira Guerra *, Suzane Ribeiro Prestes , Henrique Silveira , Leila Ines de Aguiar ˆ 1,4 4 4 5 Raposo Camara Coelho , Pricila Gama , Aristoteles Moura , Valdir Amato , Maria das Grac¸as Vale Barbosa1,2, Luiz Carlos de Lima Ferreira1,4 1Tropical Medicine Foundation of Amazonas, Manaus, Amazonas, Brazil, 2 University of the State of Amazonas, Manaus, Amazonas, Brazil, 3 Center for Malaria and other Tropical Diseases, UEI Malaria, Institute of Hygiene and Tropical Medicine of Lisboa, New University of Lisboa, Lisboa, Portugal, 4 Federal University of Amazonas, Manaus, ˜ ˜ ˜ Amazonas, Brazil, 5 University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil Abstract Background: Leishmania (Viannia) braziliensis is a parasite recognized as the most important etiologic agent of mucosal leishmaniasis (ML) in the New World. In Amazonia, seven different species of Leishmania, etiologic agents of human Cutaneous Leishmaniasis, have been described. Isolated cases of ML have been described for several different species of Leishmania: L. (V.) panamensis, L. (V.) guyanensis and L. (L.) amazonensis. Methodology: Leishmania species were characterized by polymerase chain reaction (PCR) of tissues taken from mucosal biopsies of Amazonian patients who were diagnosed with ML and treated at the Tropical Medicine Foundation of Amazonas (FMTAM) in Manaus, Amazonas state, Brazil. Samples wer