n-butyl benzyl phthalate promotes breast cancer progression by inducing expression of lymphoid enhancer factor 1邻苯二甲酸二正丁基苄促进乳腺癌发展淋巴的诱导表达增强因子1.pdfVIP

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n-butyl benzyl phthalate promotes breast cancer progression by inducing expression of lymphoid enhancer factor 1邻苯二甲酸二正丁基苄促进乳腺癌发展淋巴的诱导表达增强因子1.pdf

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n-butyl benzyl phthalate promotes breast cancer progression by inducing expression of lymphoid enhancer factor 1邻苯二甲酸二正丁基苄促进乳腺癌发展淋巴的诱导表达增强因子1

n-Butyl Benzyl Phthalate Promotes Breast Cancer Progression by Inducing Expression of Lymphoid Enhancer Factor 1 1 1 1 2,3 1 1 Tsung-Hua Hsieh , Cheng-Fang Tsai , Chia-Yi Hsu , Po-Lin Kuo , Edward Hsi , Jau-Ling Suen , Chih- 4 3,7 3,5 6 1,3,7 Hsing Hung , Jau-Nan Lee , Chee-Yin Chai , Shao-Chun Wang , Eing-Mei Tsai * 1 Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, 2 Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, 3 Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, 4 Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, 5 Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, 6 Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, 7 Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan Abstract Environmental hormones play important roles in regulating the expression of genes involved in cell proliferation, drug resistance, and breast cancer risk; however, their precise role in human breast cancer cells during cancer progression remains unclear. To elucidate the effect of the most widely used industrial phthalate, n-butyl benzyl phthalate (BBP), on cancer progression, we evaluated the results of BBP treatment using a whole human genome cD