musical aptitude is associated with avpr1a-haplotypes音乐能力与avpr1a-haplotypes相关联.pdfVIP

Musical Aptitude Is Associated with AVPR1A-Haplotypes 1 ¨ 2 3 4 ¨ ¨ 1,5 Liisa T. Ukkola *, Paivi Onkamo , Pirre Raijas , Kai Karma , Irma Jarvela 1 Department of Medical Genetics, University of Helsinki, Helsinki, Finland, 2 Department of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland, 3 Sibelius Academy, DocMus Department, Helsinki, Finland, 4 Sibelius Academy, Department of Music Education, Helsinki, Finland, 5 Laboratory of Molecular Genetics, Helsinki University Central Hospital, Helsinki, Finland Abstract Artistic creativity forms the basis of music culture and music industry. Composing, improvising and arranging music are complex creative functions of the human brain, which biological value remains unknown. We hypothesized that practicing music is social communication that needs musical aptitude and even creativity in music. In order to understand the neurobiological basis of music in human evolution and communication we analyzed polymorphisms of the arginine vasopressin receptor 1A (AVPR1A), serotonin transporter (SLC6A4), catecol-O-methyltranferase (COMT), dopamin receptor D2 (DRD2) and tyrosine hydroxylase 1 (TPH1), genes associated with social bonding and cognitive functions in 19 Finnish families (n = 343 members) with professional musicians and/or active amateurs. All family members were tested for musical aptitude using the auditory structuring ability test (Karma Music test; KMT) and Carl Seashores tests for pitch (SP) and for time (ST). Data on creativity in music (composing, improvising and/or arranging music) was surveyed using a web-based questionnaire. Here we show for the first time that creative functions in music have a strong genetic component (h2 = .84; composing h2 = .40; arranging h2 = .46;