有哪些信誉好的足球投注网站mutation k42r in ribosomal protein s12 does not affect susceptibility of mycobacterium smegmatis 16s rrna a-site mutants to 2-deoxystreptamines在核糖体蛋白突变k42r s12并不影响易感性的分枝杆菌smegmatis 16 s rrna网站2-deoxystreptamines突变体.pdfVIP
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mutation k42r in ribosomal protein s12 does not affect susceptibility of mycobacterium smegmatis 16s rrna a-site mutants to 2-deoxystreptamines在核糖体蛋白突变k42r s12并不影响易感性的分枝杆菌smegmatis 16 s rrna网站2-deoxystreptamines突变体
Mutation K42R in Ribosomal Protein S12 Does Not Affect Susceptibility of Mycobacterium smegmatis 16S rRNA A-Site Mutants to 2-Deoxystreptamines 1 1,2 ¨ 1 1 Sarath K. Kalapala , Sven N. Hobbie , Erik C. Bottger , Dmitry Shcherbakov * ¨ ¨ ¨ ¨ 1 Institut fur Medizinische Mikrobiologie, Universitat Zurich, Zurich, Switzerland, 2 Singapore-MIT Alliance for Research and Technology (SMART), Centre for Life Sciences, Singapore, Singapore Abstract Recent studies have suggested that ribosomal protein S12 modulates 16S rRNA function and susceptibility to 2- deoxystreptamine aminoglycosides. To study whether the non-restrictive K42R mutation in RpsL affects 2-deoxystreptamine susceptibility in Mycobacterium smegmatis, we studied the drug susceptibility pattern of various mutants with genetic alterations in the 16S rRNA decoding A-site in the context of wild-type and mutant protein S12. RpsL K42R substitution was found not to affect the drug resistance pattern associated with mutational alterations in 16S rRNA H44. ¨ Citation: Kalapala SK, Hobbie SN, Bottger EC, Shcherbakov D (2010) Mutation K42R in Ribosomal Protein S12 Does Not Affect Susceptibility of Mycobacterium smegmatis 16S rRNA A-Site Mutants to 2-Deoxystreptamines. PLoS ONE 5(8): e11960. doi:10.1371/journal.pone.0011960 Editor: Anil Kumar Tyagi, University of Delhi, India Received April 30, 2010; Accepted June 5, 2010; Published August 5, 2010 Copyright: 2010 Kalapala et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction
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