multidrug-resistant tuberculosis in admitted patients at a tertiary referral hospital of bangladesh耐多药结核病的三级转诊医院承认患者的孟加拉国.pdfVIP

Multidrug-Resistant Tuberculosis in Admitted Patients at a Tertiary Referral Hospital of Bangladesh 1 2 1 1 Sayera Banu *, Asif Mujtaba Mahmud , Md. Toufiq Rahman , Arman Hossain , Mohammad Khaja 1 1 1 2 3 Mafij Uddin , Tahmeed Ahmed , Razia Khatun , Wahiduzzaman Akhanda , Roland Brosch 1 International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh, 2 National Institute of Diseases of Chest and Hospital, Dhaka, Bangladesh, 3 Institut Pasteur, Integrated Mycobacterial Pathogenomics Unit, Paris, France Abstract Background: This study was set out to investigate the magnitude, patterns and molecular characterization of drug-resistant Mycobacterium tuberculosis strains at a tertiary referral hospital in Bangladesh. Methods: Pulmonary tuberculosis (TB) patients admitted at National Institute of Diseases of the Chest and Hospital from February 2002 to September 2005 with or without previous history of TB and/or other complications were randomly interviewed. Among 265 participants enrolled, M. tuberculosis isolates from 189 patients were finally tested for susceptibility to rifampicin (RMP), isoniazid (INH), ethambutol (ETM) and streptomycin (STM). Genotyping of M. tuberculosis was done using deletion analysis and spoligotyping. Results: Eighty-eight percent (n = 167) of the patients had history of previous anti-TB treatment while the remaining 12% were new TB cases. Of the 189 isolates, 9% were fully susceptible to the first line anti-TB drugs and 73.5% were multi-drug resistant TB. Other susceptibility results showed 79.4%, 77.2%, 76.7% and 78.8% resistance to IN