有哪些信誉好的足球投注网站most caenorhabditis elegans micrornas are individually not essential for development or viability最秀丽隐杆线虫microrna单独不发展或生存能力的必要条件.pdfVIP
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most caenorhabditis elegans micrornas are individually not essential for development or viability最秀丽隐杆线虫microrna单独不发展或生存能力的必要条件
Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability 1,2¤a[ 1,2[ 3[¤b 4¤c 1,2¤d Eric A. Miska , Ezequiel Alvarez-Saavedra , Allison L. Abbott , Nelson C. Lau , Andrew B. Hellman , Shannon M. McGonagle1,2¤e 1,2,4 3 1,2* , David P. Bartel , Victor R. Ambros , H. Robert Horvitz 1 Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 2 Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 3 Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire, United States of America, 4 Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America MicroRNAs (miRNAs), a large class of short noncoding RNAs found in many plants and animals, often act to post- transcriptionally inhibit gene expression. We report the generation of deletion mutations in 87 miRNA genes in Caenorhabditis elegans, expanding the number of mutated miRNA genes to 95, or 83% of known C. elegans miRNAs. We find that the majority of miRNAs are not essential for the viability or development of C. elegans, and mutations in most miRNA genes do not result in grossly abnormal phenotypes. These observations are consistent with the hypothesis that there is significant functional redundancy among miRNAs or among gene pathways regulated by miRNAs. This study represents the first comprehensive genetic analysis of miRNA function in any organism and provides a unique, permanent re
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