human trim gene expression in response to interferons人类削减对干扰素的基因表达.pdfVIP

Human TRIM Gene Expression in Response to Interferons 1,2 3 4 3 4 Laetitia Carthagena , Anna Bergamaschi , Joseph M. Luna , Annie David , Pradeep D. Uchil , Florence 1,2 4 1,2,5¤ 1,2 3 Margottin-Goguet , Walther Mothes , Uriel Hazan , Catherine Transy , Gianfranco Pancino , ´ 1,2,5* Sebastien Nisole ´ ´ ´ ´ 1 Institut Cochin, Universite Paris Descartes, CNRS (UMR 8104), Departement des Maladies Infectieuses, Paris, France, 2 INSERM U567, Paris, France, 3 Unite de Regulation ´ des Infections Retrovirales, Institut Pasteur, Paris, France, 4 Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States ´ of America, 5 Universite Paris Diderot-Paris 7, UFR des Sciences du Vivant, Paris, France Abstract Background: Tripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5a in primate cells has stimulated much interest in the potential role of TRIM proteins in antiviral activities and innate immunity. Principal Findings: To test if TRIM genes are up-regulated during antiviral immune responses, we performed a systematic analysis of TRIM gene expression in human primary lymphocytes and monocyte-derived macrophages in response to interferons (IFNs, typ