human rhinovirus infections in rural thailand epidemiological evidence for rhinovirus as both pathogen and bystander在泰国农村人类鼻病毒感染流行病学证据为鼻病毒病原体和旁观者.pdfVIP

Human Rhinovirus Infections in Rural Thailand: Epidemiological Evidence for Rhinovirus as Both Pathogen and Bystander 1 2 3 4 5 Alicia M. Fry *, Xiaoyan Lu , Sonja J. Olsen , Malinee Chittaganpitch , Pongpun Sawatwong , Somrak 5 5 2 Chantra , Henry C. Baggett , Dean Erdman 1 Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America, 2 Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America, 3 Division of Emerging Infections and Surveillance Services, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America, 4 National Institute of Health, Thailand Ministry of Public Health, Nonthaburi, Thailand, 5 International Emerging Infections Program, Thai MOPH-U.S.CDC Collaboration, Nonthaburi, Thailand Abstract Background: We describe human rhinovirus (HRV) detections in SaKaeo province, Thailand. Methods: From September 1, 2003–August 31, 2005, we tested hospitalized patients with acute lower respiratory illness and outpatient controls without fever or respiratory symptoms for HRVs with polymerase chain reaction and molecularly- typed select HRVs. We compared HRV detection among hospitalized patients and controls and estimated enrollment adjusted incidence. Results: HRVs were detected in 315 (16%) of 1919 hospitalized patients and 27 (9.6%) of 280 controls. Children had the highest frequency of HRV detections (hospitalized: ,1 year: 29%, 1–4 year: 29%, $65 years: 9%; controls: ,1 year: 24%, 1–4 year: 14%, $65 years: 2.8%). Enrollment adjusted hospitalized HRV detection rates were highest among persons aged ,1 year (1038/100,000 persons/year), 1–4 years (4