human telomere length correlates to the size of the associated chromosome arm人类端粒长度与相关的染色体臂的大小.pdfVIP

Human Telomere Length Correlates to the Size of the Associated Chromosome Arm 1 2 2 3 4 Jasen L. Wise *, Richard J. Crout , Daniel W. McNeil , Robert J. Weyant , Mary L. Marazita , Sharon L. Wenger1 1 Department of Pathology, West Virginia University, Morgantown, West Virginia, United States of America, 2 School of Dentistry, West Virginia University, Morgantown, West Virginia, United States of America, 3 Department of Dental Public Health and Information Management, University of Pittsburgh School of Dental Medicine, Pittsburgh, Pennsylvania, United States of America, 4 Center for Craniofacial and Dental Genetics, Departments of Oral Biology and Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Abstract The majority of human telomere length studies have focused on the overall length of telomeres within a cell. In fact, very few studies have examined telomere length for individual chromosome arms. The objective of this study was to examine the relationship between chromosome arm size and the relative length of the associated telomere. Quantitative Fluorescence In Situ Hybridization (Q-FISH) was used to measure the relative telomere length of each chromosome arm in metaphases from cultured lymphocytes of 17 individuals. A statistically significant positive correlation (r = 0.6) was found between telomere length and the size of the associated chromosome arm, which was estimated based on megabase pair measurements from /projects/mapview/. Citation: Wise JL, Crout RJ, McNeil DW, Weyant RJ, Marazita ML, et al. (2009) Human Telomere Length Correlates to the Size of the Associated Chromosome Arm. PLoS ONE 4(6): e6013. doi:10.1371/journal.pone.0006013