有哪些信誉好的足球投注网站identification of candidate gene regions in the rat by co-localization of qtls for bone density, size, structure and strength候选基因的识别区域涉及的qtl co-localization大鼠的骨密度,大小、结构和强度.pdfVIP
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identification of candidate gene regions in the rat by co-localization of qtls for bone density, size, structure and strength候选基因的识别区域涉及的qtl co-localization大鼠的骨密度,大小、结构和强度
Identification of Candidate Gene Regions in the Rat by Co-Localization of QTLs for Bone Density, Size, Structure and Strength 1 2 2 4 1 Sofia Lagerholm , Hee-Bok Park , Holger Luthman , Marc Grynpas , Fiona McGuigan , Maria 1 ˚ 1,3 Swanberg , Kristina Akesson * ¨ 1 Clinical and Molecular Osteoporosis Unit, Department of Clinical Sciences Malmo, Lund University, Lund, Sweden, 2 Medical Genetics Unit, Department of Clinical ¨ ˚ ¨ ¨ Sciences Malmo, Lund University, Lund, Sweden, 3 Department of Orthopedics, Skane University Hospital Malmo, Malmo, Sweden, 4 Institute of Biomaterials and Biomedical Engineering, University of Toronto and Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Toronto, Canada Abstract Susceptibility to osteoporotic fracture is influenced by genetic factors that can be dissected by whole-genome linkage analysis in experimental animal crosses. The aim of this study was to characterize quantitative trait loci (QTLs) for biomechanical and two-dimensional dual-energy X-ray absorptiometry (DXA) phenotypes in reciprocal F2 crosses between diabetic GK and normo-glycemic F344 rat strains and to identify possible co-localization with previously reported QTLs for bone size and structure. The biomechanical measurements of rat tibia included ultimate force, stiffness and work to failure while DXA was used to characterize tibial area, bone mineral
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