有哪些信誉好的足球投注网站identification of biological markers of liver x receptor (lxr) activation at the cell surface of human monocytes识别的生物标记肝x受体(lxr)激活人类单核细胞在细胞表面.pdfVIP
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identification of biological markers of liver x receptor (lxr) activation at the cell surface of human monocytes识别的生物标记肝x受体(lxr)激活人类单核细胞在细胞表面
Identification of Biological Markers of Liver X Receptor (LXR) Activation at the Cell Surface of Human Monocytes ´ ´ ´ 1,2,3 2 2 ´ 1,2,3 Cedric Rebe , Rodolphe Filomenko , Magalie Raveneau , Angelique Chevriaux , 1,2 1,2,4 2 1,2,4 1,2,4 Minako Ishibashi , Laurent Lagrost , Jean Louis Junien , Philippe Gambert , David Masson * ´ ´ ´ ´ 1 Centre de Recherche Institut National de la Sante et de la Recherche Medicale Unite Mixte de Recherche 866, Universite de Bourgogne, Dijon, France, 2 Structure ´ ´ ´ ´ Federative de Recherche Sante-Sciences et Techniques de l’Information et de la Communication, Universite de Bourgogne, Dijon, France, 3 Centre Georges-Franc¸ois Leclerc, Dijon, France, 4 Centre Hospitalier Universitaire Dijon, Dijon, France Abstract Background: Liver X receptor (LXR) a and LXR b (NR1H3 and NR1H2) are oxysterol-activated nuclear receptors involved in the control of major metabolic pathways such as cholesterol homeostasis, lipogenesis, inflammation and innate immunity. Synthetic LXR agonists are currently under development and could find applications in various fields such as cardiovascular diseases, cancer, diabetes and neurodegenerative diseases. The clinical development of LXR agonists
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