histo-blood group gene polymorphisms as potential genetic modifiers of infection and cystic fibrosis lung disease severityhisto-blood组基因多态性作为潜在的遗传修饰符的感染和囊性纤维化肺病严重性.pdfVIP

Histo-Blood Group Gene Polymorphisms as Potential Genetic Modifiers of Infection and Cystic Fibrosis Lung Disease Severity 1 2 3 2 Jennifer L. Taylor-Cousar *, Maimoona A. Zariwala , Lauranell H. Burch , Rhonda G. Pace , Mitchell L. 6 2 5 5 4 2 Drumm , Hollin Calloway , Haiying Fan , Brent W. Weston , Fred A. Wright , Michael R. Knowles for the Gene Modifier Study Group 1 University of New Mexico Health Sciences Center, Pulmonary Divisions, Internal Medicine and Pediatrics, Albuquerque, New Mexico, United States of America, 2 University of North Carolina, Cystic Fibrosis/Pulmonary Research and Treatment Center, Chapel Hill, North Carolina, United States of America, 3 National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America, 4 University of North Carolina, Department of Biostatistics, Chapel Hill, North Carolina, United States of America, 5 University of North Carolina, Hematology-Oncology, Department of Pediatrics, Chapel Hill, North Carolina, United States of America, 6 Case Western Reserve University, Pediatric Pulmonary Division, Department of Pediatrics, Cleveland, Ohio, United States of America Abstract Background: The pulmonary phenotype in cystic fibrosis (CF) is variable; thus, environmental and genetic factors likely contribute to clinical heterogeneity. We hypothesized that genetically determined ABO histo-blood group antigen (ABH) differences in glycosylation may lead to differences in microbial binding by airway mucus, and thus predispose to early lung infection and more severe lung disease in a