hiv-1 residual viremia correlates with persistent t-cell activation in poor immunological responders to combination antiretroviral therapyhiv - 1残余病毒血症与持续贫困免疫反应激活t细胞联合抗逆转录病毒治疗.pdfVIP
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hiv-1 residual viremia correlates with persistent t-cell activation in poor immunological responders to combination antiretroviral therapyhiv - 1残余病毒血症与持续贫困免疫反应激活t细胞联合抗逆转录病毒治疗
HIV-1 Residual Viremia Correlates with Persistent T-Cell Activation in Poor Immunological Responders to Combination Antiretroviral Therapy 1 1,2,3 1,4 1,4 Maud Mavigner , Pierre Delobel , Michelle Cazabat , Martine Dubois , Fatima-Ezzahra L’Faqihi- 1 ´ 1,2,4 1,2,4 2,3 2,3 Olive , Stephanie Raymond , Christophe Pasquier , Bruno Marchou , Patrice Massip , Jacques Izopet1,2,4* ´ ˆ 1 INSERM, U563, Toulouse, France, 2 Universite Toulouse III Paul-Sabatier, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France, 3 CHU Toulouse, Hopital ˆ Purpan, Service des Maladies Infectieuses et Tropicales, Toulouse, France, 4 CHU Toulouse, Hopital Purpan, Laboratoire de Virologie, Toulouse, France Abstract Background: The clinical significance and cellular sources of residual human immunodeficiency virus type 1 (HIV-1) production despite suppressive combination antiretroviral therapy (cART) remain unclear and the effect of low-level viremia on T-cell homeostasis is still debated. Methodology/Principal Findings: We characterized the recently produced residual viruses in the plasma and short-lived blood monocytes of 23 patients with various immunological responses to sustained suppressive cART. We quantifi
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