有哪些信誉好的足球投注网站histidine protects against zinc and nickel toxicity in caenorhabditis elegans组氨酸在秀丽隐杆线虫防止锌和镍的毒性.pdfVIP
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histidine protects against zinc and nickel toxicity in caenorhabditis elegans组氨酸在秀丽隐杆线虫防止锌和镍的毒性
Histidine Protects Against Zinc and Nickel Toxicity in Caenorhabditis elegans 1 1¤ 1 1 2 John T. Murphy , Janelle J. Bruinsma , Daniel L. Schneider , Sara Collier , James Guthrie , Asif 3 2,4 3 1 Chinwalla , J. David Robertson , Elaine R. Mardis , Kerry Kornfeld * 1 Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America, 2 Research Reactor Center, University of Missouri, Columbia, Missouri, United States of America, 3 The Genome Center, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America, 4 Department of Chemistry, University of Missouri, Columbia, Missouri, United States of America Abstract Zinc is an essential trace element involved in a wide range of biological processes and human diseases. Zinc excess is deleterious, and animals require mechanisms to protect against zinc toxicity. To identify genes that modulate zinc tolerance, we performed a forward genetic screen for Caenorhabditis elegans mutants that were resistant to zinc toxicity. Here we demonstrate that mutations of the C. elegans histidine ammonia lyase (haly-1) gene promote zinc tolerance. C. elegans haly- 1 encodes a protein that is homologous to vertebrate HAL, an enzyme that converts histidine to urocanic acid. haly-1 mutant animals displayed elevated levels of histidine, indicating that C. elegans HALY-1 protein is an enzyme involved in histidine catabolism. These results suggest the model that elevated histidine chelates zinc and thereby reduces zinc toxicity. Supporting
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