glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations胶质母细胞瘤子类可以定义活动之间的信号转导途径和相关基因的改变.pdfVIP

Glioblastoma Subclasses Can Be Defined by Activity among Signal Transduction Pathways and Associated Genomic Alterations 1,2. 3. 1,2 3 Cameron Brennan *, Hiroyuki Momota , Dolores Hambardzumyan , Tatsuya Ozawa , Adesh 1 1 1,2,3,4,5 Tandon , Alicia Pedraza , Eric Holland * 1 Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America, 2 Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America, 3 Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America, 4 Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America, 5 Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America Abstract Background: Glioblastoma multiforme (GBM) is an umbrella designation that includes a heterogeneous group of primary brain tumors. Several classification strategies of GBM have been reported, some by clinical course and others by resemblance to cell types either in the adult or during development. From a practical and therapeutic standpoint, classifying GBMs by signal transduction pathway activation and by mutation in pathway member genes may be particularly valuable for the development of targeted therapies. Methodology/Principal Findings: We performed targeted proteomic analysis of 27 surgical glioma samples to identify patterns of coordinate activation among glioma-relevant signal transduction pathways, then compared these results with integrated