有哪些信誉好的足球投注网站hco3？cl？ exchange inactivation and reactivation during mouse oocyte meiosis correlates with mekmapk-regulated ae2 plasma membrane localizationhco3 cl 交换失活和再生在小鼠卵母细胞减数分裂与mekmapk-regulated ae2质膜定位.pdfVIP
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hco3？cl？ exchange inactivation and reactivation during mouse oocyte meiosis correlates with mekmapk-regulated ae2 plasma membrane localizationhco3 cl 交换失活和再生在小鼠卵母细胞减数分裂与mekmapk-regulated ae2质膜定位
HCO32/Cl 2 Exchange Inactivation and Reactivation during Mouse Oocyte Meiosis Correlates with MEK/ MAPK-Regulated Ae2 Plasma Membrane Localization 1,2 1,3,4 1,3,4 5 1,2,3 Chenxi Zhou , Mario Tiberi , Binhui Liang , Seth L. Alper , Jay M. Baltz * 1 Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, 2 Division of Reproductive Medicine, Department of Obstetrics and Gynecology, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada, 3 Department of Cellular and Molecular Medicine, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada, 4 Departments of Psychiatry and Medicine, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada, 5 Molecular and Vascular Medicine Unit and Renal Division, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America Abstract Background: Germinal Vesicle (GV) stage mouse oocytes in first meiotic prophase exhibit highly active HCO32/Cl 2 exchange—a class of transport nearly ubiquitously involved in regulation of intracellular pH and cell volume. During meiosis, however, oocyte HCO32/Cl 2 exchange becomes inactivated during first metaphase (MI), remains inactive in second metaphase (MII), and is reactivated only after egg activation. Previous work using pharmacological manipulations had indicated that activity of the MEK/MAPK signaling pathway was negatively correlated with HCO32/Cl 2 exchange activity during meiosis. However, the mechanism by which the exchanger is inactivated during meiotic progression had not been determined, nor had the role of MEK/MAPK been directly established. Methodology/Pr
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