hcv coinfection associated with slower disease progression in hiv-infected former plasma donors na？ve to art丙肝病毒合并感染hiv感染前等离子体中与疾病进展放缓有关捐助者na 艺术.pdfVIP

HCV Coinfection Associated with Slower Disease ¨ Progression in HIV-Infected Former Plasma Donors Naıve to ART 1. 1,2. 1 1 1 1 3 Xiaoyan Zhang , Jianqing Xu , Hong Peng , Yan Ma , Lifeng Han , Yuhua Ruan , Bing Su , Ning 1 1 Wang , Yiming Shao * 1 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing, China, 2 Shanghai Public Health Clinical Center the Institutes of Biomedical Sciences, Fudan University, Shanghai, China, 3 Anhui Provincial Center for Disease Control and Prevention, Hefei, China Abstract Background: It remains controversial how HCV coinfection influences the disease progression during HIV-1 infection. This study aims to define the influence of HCV infection on the replication of HIV-1 and the disease progression in HIV-infected ¨ former plasma donors (FPDs) naıve to ART. Methodology/Principal Findings: 168 HIV-1-infected FPDs were enrolled into a cohort study from Anhui province in central China, and thereafter monitored at month 3, 9, 15, 21 and 33. Fresh whole blood samples were used for CD4+ T-cell counting. Their plasma samples were collected and stored for quantification of HIV-1 viral loads and for determination of HCV and Toxoplasma. Out of 168 HIV-infected FBDs, 11.9% (20 cases), 80.4% (135 cases) and 7.7% (13 cases) were infected with HIV-1 alone, HIV-1/HCV and HIV/HCV/Toxoplasma, respectively. During the 33-month follow-up, only 35% (7 out of 20 cases) HIV-1 mono-infected subject