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genome-wide association analysis of autoantibody positivity in type 1 diabetes cases全基因组关联分析自身抗体在1型糖尿病的情况下积极
Genome-Wide Association Analysis of Autoantibody Positivity in Type 1 Diabetes Cases 1 1 1 1 1 Vincent Plagnol *, Joanna M. M. Howson , Deborah J. Smyth , Neil Walker , Jason P. Hafler , Chris 1 1 2 3 Wallace , Helen Stevens , Laura Jackson , Matthew J. Simmonds , Type 1 Diabetes Genetics 4 3 1 Consortium, Polly J. Bingley , Stephen C. Gough , John A. Todd * 1Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Biomedical Research Centre, University of Cambridge, Cambridge, United Kingdom, 2 University Hospitals Birmingham, Birmingham, United Kingdom, 3 The Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Headington, Oxford, United Kingdom, 4 School of Clinical Sciences, University of Bristol, Bristol, United Kingdom Abstract The genetic basis of autoantibody production is largely unknown outside of associations located in the major histocompatibility complex (MHC) human leukocyte antigen (HLA) region. The aim of this study is the discovery of new genetic associations with autoantibody positivity using genome-wide association scan single nucleotide polymorphism (SNP) data in type 1 diabetes (T1D) patients with autoantibody measurements. We measured two anti-islet autoantibodies, glutamate decarboxylase (GADA, n = 2,506), insulinoma-associated antigen 2 (IA-2A, n = 2,498), antibodies to the
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