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genetic variation in healthy oldest-old遗传变异在健康的长寿老人
Genetic Variation in Healthy Oldest-Old 1 1 1 1 Julius Halaschek-Wiener , Mahsa Amirabbasi-Beik , Nasim Monfared , Markus Pieczyk , Christian 1,2 1 1 1 1 1 Sailer , Anita Kollar , Ruth Thomas , Georgios Agalaridis , So Yamada , Lisa Oliveira , Jennifer A. 1 3 1 3 4 5 Collins , Graydon Meneilly , Marco A. Marra , Kenneth M. Madden , Nhu D. Le , Joseph M. Connors , Angela R. Brooks-Wilson1,6* 1 Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, 2 Institute of Plant Biology, University of ¨ ¨ Zurich, Zurich, Switzerland, 3 Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada, 4 Cancer Control Research, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, 5 Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, 6 Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada Abstract Individuals who live to 85 and beyond without developing major age-related diseases may achieve this, in part, by lacking disease susceptibility factors, or by possessing resistance factors that enhance their ability to avoid disease and prolong lifespan. Healthy aging is a complex phenotype likely to be affected by both genetic and environmental factors. We sequenced 24 candidate healthy aging genes in DNA samples from 47 healthy individuals aged eighty-five years o
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