gender difference in the prognostic role of interleukin 6 in oral squamous cell carcinoma性别差异在预后白介素6在口腔鳞状细胞癌中的作用.pdfVIP

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gender difference in the prognostic role of interleukin 6 in oral squamous cell carcinoma性别差异在预后白介素6在口腔鳞状细胞癌中的作用.pdf

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gender difference in the prognostic role of interleukin 6 in oral squamous cell carcinoma性别差异在预后白介素6在口腔鳞状细胞癌中的作用

Gender Difference in the Prognostic Role of Interleukin 6 in Oral Squamous Cell Carcinoma 1,2,3,4,5 1,2,5 3,4 5,6 4 Chih-Jung Chen , Wen-Wei Sung , Yueh-Min Lin , Mu-Kuan Chen , Ching-Hsiao Lee , 1,2 . 3,5 . 1,2,7 . Huei Lee * , Kun-Tu Yeh * , Jiunn-Liang Ko * 1 Institute of Medicine, Chung Shan Medical University, Taichuang, Taiwan, 2 Institute of Medical and Molecular Toxicology, Chung Shan Medical University, Taichuang, Taiwan, 3 Department of Surgical Pathology, Changhua Christian Hospital, Changhua, Taiwan, 4 Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan, 5 School of Medicine, Chung Shan Medical University, Taichuang, Taiwan, 6 Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan, 7 Department of Medical Oncology and Chest Medicine, Chung Shan Medical University Hospital, Taichuang, Taiwan Abstract Background: Interleukin 6 (IL6) plays an important role in immunoregulation and tumorigenesis in human cancers. Oral squamous cell carcinoma (OSCC) is a malignant tumor of the oral cavity with a male predominant tendency and a poor clinical prognosis. Due to the relatively few cases in females, the gender difference of prognostic markers for OSCC is seldom discussed. Methods: In this study, we used immunohistochemical staining methods to investigate the associations between IL6 expression and the clinicopathological characteristics of OSCC. In addition, we collected 74 female and 263 male OSCC patients for evaluation. Results: High IL6 expression in tumor c