有哪些信誉好的足球投注网站genetic variation in selenoprotein genes, lifestyle, and risk of colon and rectal cancer遗传变异在硒蛋白基因、生活方式和结肠癌和直肠癌的风险.pdfVIP
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genetic variation in selenoprotein genes, lifestyle, and risk of colon and rectal cancer遗传变异在硒蛋白基因、生活方式和结肠癌和直肠癌的风险
Genetic Variation in Selenoprotein Genes, Lifestyle, and Risk of Colon and Rectal Cancer 1 1 2 2 1 Martha L. Slattery *, Abbie Lundgreen , Bill Welbourn , Christopher Corcoran , Roger K. Wolff 1 Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, United States of America, 2 Department of Mathematics and Statistics, Utah State University, Logan, Utah, United States of America Abstract Background: Associations between selenium and cancer have directed attention to role of selenoproteins in the carcinogenic process. Methods: We used data from two population-based case-control studies of colon (n = 1555 cases, 1956 controls) and rectal (n = 754 cases, 959 controls) cancer. We evaluated the association between genetic variation in TXNRD1, TXNRD2, TXNRD3, C11orf31 (SelH), SelW, SelN1, SelS, SepX, and SeP15 with colorectal cancer risk. Results: After adjustment for multiple comparisons, several associations were observed. Two SNPs in TXNRD3 were associated with rectal cancer (rdominant OR 1.42 95% CI 1.16,1.74 pACT 0.0036 and rs9637365 recessive 0.70 95% CI 0.55,0.90 pACT 0.0208). Four SNPs in SepN1 were associated with rectal cancer (rrecessive OR 1.30 95% CI 1.04,1.63 pACT 0.0410; rs2072749 GGvsAA OR 0.53 95% CI 0.36,0.80 pACT 0.0159; rs4659382 recessive OR 0.58 95% CI 0.39,0.86 pACT 0.0247; rs718391 dominant OR 0.76 95% CI 0.62,0.94 pACT 0.0300). Interaction between these genes and exposures that could influence these genes showed numerous significant associations after adjustment for multiple comparisons. Two SNPs in TXNRD1 and four SNPs in TXNRD2 int
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