有哪些信誉好的足球投注网站genetic variation in the plasmodium falciparum circumsporozoite protein in india and its relevance to rts,s malaria vaccine遗传变异在印度的恶性疟原虫环子孢子蛋白及其相关性rts,s疟疾疫苗.pdfVIP
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genetic variation in the plasmodium falciparum circumsporozoite protein in india and its relevance to rts,s malaria vaccine遗传变异在印度的恶性疟原虫环子孢子蛋白及其相关性rts,s疟疾疫苗
Genetic Variation in the Plasmodium falciparum Circumsporozoite Protein in India and Its Relevance to RTS,S Malaria Vaccine 1. 1. 1 1 Mohammad Zeeshan , Mohammad Tauqeer Alam , Sumiti Vinayak , Hema Bora , Rupesh 1 1 1 1 1 Kumar Tyagi , Mohd Shoeb Alam , Vandana Choudhary , Pooja Mittra , Vanshika Lumb , Praveen 2 3 2 2 2 Kumar Bharti , Venkatachalam Udhayakumar , Neeru Singh , Vidhan Jain , Pushpendra Pal Singh , Yagya Dutta Sharma1* 1 Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India, 2 Regional Medical Research Centre for Tribals, Jabalpur, Madhya Pradesh, India, 3 Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America Abstract RTS,S is the most advanced malaria vaccine candidate, currently under phase-III clinical trials in Africa. This Plasmodium falciparum vaccine contains part of the central repeat region and the complete C-terminal T cell epitope region (Th2R and Th3R) of the circumsporozoite protein (CSP). Since naturally occurring polymorphisms at the vaccine candidate loci are critical determinants of the protective efficacy of the vaccines, it is imperative to investigate these polymorphisms in field isolates. In this study we have investigated the genetic diversity at the central repeat, C-terminal T cell epitope (Th2R and Th3R) and N-terminal
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