有哪些信誉好的足球投注网站genetic variants in marco are associated with the susceptibility to pulmonary tuberculosis in chinese han population与易感性相关的遗传变异在马可在中国汉族人口肺结核.pdfVIP
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genetic variants in marco are associated with the susceptibility to pulmonary tuberculosis in chinese han population与易感性相关的遗传变异在马可在中国汉族人口肺结核
Genetic Variants in MARCO Are Associated with the Susceptibility to Pulmonary Tuberculosis in Chinese Han Population 1 2 1 3 3 4 5 Mai-Juan Ma , Hai-Bing Wang , Hao Li , Jun-Hai Yang , Yan Yan , Lan-Pin Xie , Ying-Cheng Qi , Jun-Lian 5 5 1 1 Li , Mei-Juan Chen , Wei Liu *, Wu-Chun Cao * 1 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People’s Republic of China, 2 Department of Tuberculosis, Shijiazhuang Fifth Hospital, Hebei, People’s Republic of China, 3 Physical Examination Department, Beijing Electronic Hospital, Beijing, People’s Republic of China, 4 Department of Tuberculosis, Hebei Chest Hospital, Hebei, People’s Republic of China, 5 Xinjiang Uygur Autonomous Region Chest Hospital, Urumqi, People’s Republic of China Abstract Background: Susceptibility to tuberculosis is not only determined by Mycobacterium tuberculosis infection, but also by the genetic component of the host. Macrophage receptor with a collagenous structure (MARCO) is essential components required for toll like receptor-signaling in macrophage response to Mycobacterium tuberculosis, which may contribute to tuberculosis risk. Principal Findings: To specifically investigated whether single nucleotide polymorphisms (SNPs) in MARCO gene are associated with pulmonary tuberculosis in Chinese Han population. By selecting tagging SNPs in MARCO gene, 17 tag SNPs were identified and genotyped in 923 pulmonary tuberculosis patients and 1033 healthy control subjects using a hospital based case-control association study. Single-point and haplotype analysis revealed an association in intron and exon region of MARCO gene. On
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