有哪些信誉好的足球投注网站genetic variants of ide-kif11-hhex at 10q23.33 associated with type 2 diabetes risk a fine-mapping study in chinese population遗传变异与2型糖尿病相关的ide-kif11-hhex 10 q23.33精细定位研究中国人口的风险.pdfVIP
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genetic variants of ide-kif11-hhex at 10q23.33 associated with type 2 diabetes risk a fine-mapping study in chinese population遗传变异与2型糖尿病相关的ide-kif11-hhex 10 q23.33精细定位研究中国人口的风险
Genetic Variants of IDE-KIF11-HHEX at 10q23.33 Associated with Type 2 Diabetes Risk: A Fine-Mapping Study in Chinese Population 1,2 1 2 2 1 2 1 1 Yun Qian *, Feng Lu , Meihua Dong , Yudi Lin , Huizhang Li , Jian Chen , Chong Shen , Guangfu Jin , 1 1 Zhibin Hu , Hongbing Shen * 1 Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China, 2 Department of Chronic Non-communicable Disease Control, Wuxi Center for Disease Control and Prevention, Wuxi, China Abstract Background: Genome-wide association studies (GWAS) in populations of European ancestry have mapped a type 2 diabetes susceptibility region to chromosome 10q23.33 containing IDE, KIF11 and HHEX genes (IDE-KIF11-HHEX), which has also been replicated in Chinese populations. However, the functional relevance for genetic variants at this locus is still unclear. It is critical to systematically assess the relationship of genetic variants in this region with the risk of type 2 diabetes. Methodology/Principal Findings: A fine-mapping study was conducted by genotyping fourteen tagging single-nucleotide polymorphisms (SNPs) in a 290-kb linkage disequilibrium (LD) region using a two-stage case-control study of type 2 diabetes in a Chinese Han population. Suggestive associations (P,0.05) observed from 1,200 cases and 1,200 controls in the first stage were further replicated in 1,725 cases and 2,081 controls in the second stage. Seven tagging SNPs were consistently associated with type 2 diabetes in both stages (P,0.05), with combined odds ratios (ORs) ranging from 1.14 to 1.33 in the combined analysis. The most significant locus was rs7923837 [OR = 1.33, 95% con
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