有哪些信誉好的足球投注网站genetic control of variegated kir gene expression polymorphisms of the bi-directional kir3dl1 promoter are associated with distinct frequencies of gene expression基因表达遗传控制组合成吉珥双向kir3dl1启动子的多态性与不同频率的基因表达有关.pdfVIP
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genetic control of variegated kir gene expression polymorphisms of the bi-directional kir3dl1 promoter are associated with distinct frequencies of gene expression基因表达遗传控制组合成吉珥双向kir3dl1启动子的多态性与不同频率的基因表达有关
Genetic Control of Variegated KIR Gene Expression: Polymorphisms of the Bi-Directional KIR3DL1 Promoter Are Associated with Distinct Frequencies of Gene Expression 1,2 ´ 2 1,2 1,2 1,2 Hongchuan Li , Veronique Pascal , Maureen P. Martin , Mary Carrington , Stephen K. Anderson * 1 Basic Research Program, SAIC-Frederick Inc., National Cancer Institute-Frederick, Frederick, Maryland, United States of America, 2 Cancer and Inflammation Program, Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland, United States of America Abstract Natural killer (NK) cells play an important role in the detection and elimination of tumors and virus-infected cells by the innate immune system. Human NK cells use cell surface receptors (KIR) for class I MHC to sense alterations of class I on potential target cells. Individual NK cells only express a subset of the available KIR genes, generating specialized NK cells that can specifically detect alteration of a particular class I molecule or group of molecules. The probabilistic behavior of human KIR bi-directional promoters is proposed to control the frequency of expression of these variegated genes. Analysis of a panel of donors has revealed the presence of several functionally relevant promoter polymorphisms clustered mainly in the inhibitory KIR family members, especially the KIR3DL1 alleles. We demonstrate for the first time that promoter polymorphisms affecting the strength of competing sense and antisense promoters largely explain the differential frequency of expression of KIR3DL1 allotypes on NK cells. KIR3DL1/S1 s
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