genetic detection and characterization of lujo virus, a new hemorrhagic fever–associated arenavirus from southern africalujo病毒基因检测和表征,一种新的出血性fever-associated沙粒病毒从非洲南部.pdfVIP

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genetic detection and characterization of lujo virus, a new hemorrhagic fever–associated arenavirus from southern africalujo病毒基因检测和表征,一种新的出血性fever-associated沙粒病毒从非洲南部.pdf

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genetic detection and characterization of lujo virus, a new hemorrhagic fever–associated arenavirus from southern africalujo病毒基因检测和表征,一种新的出血性fever-associated沙粒病毒从非洲南部

Genetic Detection and Characterization of Lujo Virus, a New Hemorrhagic Fever–Associated Arenavirus from Southern Africa 1. 2. 3 4 1 Thomas Briese *, Janusz T. Paweska , Laura K. McMullan , Stephen K. Hutchison , Craig Street , 1 5 2 2 4 Gustavo Palacios , Marina L. Khristova , Jacqueline Weyer , Robert Swanepoel , Michael Egholm , 3 1 Stuart T. Nichol , W. Ian Lipkin * 1 Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, United States of America, 2 Special Pathogens Unit, National Institute for Communicable Diseases of the National Health Laboratory Service, Sandringham, South Africa, 3 Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America, 4 454 Life Sciences, Branford, Connecticut, United States of America, 5 Biotechnology Core Facility Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America Abstract Lujo virus (LUJV), a new member of the family Arenaviridae and the first hemorrhagic fever–associated arenavirus from the Old World discovered in three decades, was isolated in South Africa during an outbreak of human disease characterized by nosocomial transmission and an unprecedented high case fatality rate of 80% (4/5 cases). Unbiased pyrosequencing of RNA extracts from serum and tissues of outbreak victims enabled identification and detailed phylogenetic characterization within 72 hours of sample receipt. Full genome analyses of LUJV showed