有哪些信誉好的足球投注网站functional screen of paracrine signals in breast carcinoma fibroblasts功能屏幕乳腺癌成纤维细胞的旁分泌信号.pdfVIP
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functional screen of paracrine signals in breast carcinoma fibroblasts功能屏幕乳腺癌成纤维细胞的旁分泌信号
Functional Screen of Paracrine Signals in Breast Carcinoma Fibroblasts 1 2 2 1,3 Gui Su , Kyung E. Sung , David J. Beebe , Andreas Friedl * 1 Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 2 Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 3 Pathology and Laboratory Medicine Service, William S. Middleton Memorial Veterans Hospital, Department of Veterans Affairs Medical Center, Madison, Wisconsin, United States of America Abstract Stromal fibroblasts actively participate in normal mammary gland homeostasis and in breast carcinoma growth and progression by secreting paracrine factors; however, little is known about the identity of paracrine mediators in individual patients. The purpose of this study was to characterize paracrine signaling pathways between breast carcinoma cells and breast carcinoma-associated fibroblasts (CAF) or normal mammary fibroblasts (NF), respectively. CAF and NF were isolated from breast carcinoma tissue samples and adjacent normal mammary gland tissue of 28 patients. The fibroblasts were grown in 3D collagen gel co-culture with T47D human breast carcinoma cells and T47D cell growth was measured. CAF stimulated T47D cell growth to a significantly greater degree than NF. We detected a considerable inter-individual heterogeneity of paracrine interactions but identified FGF2, HB-EGF, heparanase-1 and SDF1 as factors that were consistently responsible for the activity of carcinoma-associated fibroblasts. CAF from low-grade but not hi
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