genetic association analysis of the functional c.714tg polymorphism and mucosal expression of dectin-1 in inflammatory bowel diseasec基因关联分析功能。.pdfVIP
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genetic association analysis of the functional c.714tg polymorphism and mucosal expression of dectin-1 in inflammatory bowel diseasec基因关联分析功能。
Genetic Association Analysis of the Functional c.714T.G Polymorphism and Mucosal Expression of Dectin-1 in Inflammatory Bowel Disease 1 2,3 4 2,3 5 Hilbert S. de Vries , Theo S. Plantinga , J. Han van Krieken , Rinke Stienstra , Ad A. van Bodegraven , 6 6 7 8 2,3 Eleonora A. M. Festen , Rinse K. Weersma , J. Bart A. Crusius , Ronald K. Linskens , Leo A. B. Joosten , 2,3 1 Mihai G. Netea , Dirk J. de Jong * 1 Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, 2 Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, 3 Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen, The Netherlands, 4 Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, 5 Department of Gastroenterology and Hepatology, VU University Medical Centre, Amsterdam, The Netherlands, 6 Department of Gastroenterology and Hepatology, University Medical Centre Groningen, Groningen, The Netherlands, 7 Department of Pathology, Laboratory of Immunogenetics, VU University Medical Centre, Amsterdam, The Netherlands, 8 Department of Gastroenterology, Saint Anna Hospital, Geldrop, The Netherlands Abstract Background: Dectin-1 is a pattern recognition receptor (PRR) expressed by myeloid cells that specifically recognizes b-1,3 glucan, a polysaccharide and major component of the fungal cell wall. Upon activation, dectin-1 si
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