functional anatomy of the masking level difference, an fmri study屏蔽的功能解剖学水平差异,功能磁共振成像研究.pdfVIP

Functional Anatomy of the Masking Level Difference, an fMRI Study 1,2,4 1 1,3 1 4 David S. Wack *, Jennifer L. Cox , Claudiu V. Schirda , Christopher R. Magnano , Joan E. Sussman , Donald Henderson4, Robert F. Burkard5 1 Buffalo Neuroimaging Analysis Center, Dept. of Neurology, University at Buffalo, State University of New York at Buffalo, Buffalo, New York, United States of America, 2 Department of Nuclear Medicine, University at Buffalo, State University of New York at Buffalo, Buffalo, New York, United States of America, 3 MR Research Center, Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 4 Department of Communicative Disorders and Sciences, University at Buffalo, State University of New York at Buffalo, Buffalo, New York, United States of America, 5 Department of Rehabilitation Science, University at Buffalo, State University of New York at Buffalo, Buffalo, New York, United States of America Abstract Introduction: Masking level differences (MLDs) are differences in the hearing threshold for the detection of a signal presented in a noise background, where either the phase of the signal or noise is reversed between ears. We use N0/Np to denote noise presented in-phase/out-of-phase between ears and S0/Sp to denote a 500 Hz sine wave signal as in/out-of- phase. Signal detection level for the noise/signal combinations N0Sp and NpS0 is typically 10–20 dB better than for N0S0. All combinations have the same spectrum, level, and duration of both the signal and the noise. Methods: Ten participants (5 female), age: 22–43, with N0Sp-N0S0 MLDs greater than 10 dB, were imaged using a sparse BOLD fMRI sequence, with a 9 second gap (