有哪些信誉好的足球投注网站gene expression signatures of extracellular matrix and growth factors during embryonic stem cell differentiation细胞外基质和生长因子的基因表达特征在胚胎干细胞分化.pdfVIP
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gene expression signatures of extracellular matrix and growth factors during embryonic stem cell differentiation细胞外基质和生长因子的基因表达特征在胚胎干细胞分化
Gene Expression Signatures of Extracellular Matrix and Growth Factors during Embryonic Stem Cell Differentiation Rekha Nair1., Alyssa V. Ngangan1., Melissa L. Kemp1,2, Todd C. McDevitt1,2* 1The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States of America, 2 The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America Abstract Pluripotent stem cells are uniquely capable of differentiating into somatic cell derivatives of all three germ lineages, therefore holding tremendous promise for developmental biology studies and regenerative medicine therapies. Although temporal patterns of phenotypic gene expression have been relatively well characterized during the course of differentiation, coincident patterns of endogenous extracellular matrix (ECM) and growth factor expression that accompany pluripotent stem cell differentiation remain much less well-defined. Thus, the objective of this study was to examine the global dynamic profiles of ECM and growth factor genes associated with early stages of pluripotent mouse embryonic stem cell (ESC) differentiation. Gene expression analysis of ECM and growth factors by ESCs differentiating as embryoid bodies for up to 14 days was assessed using PCR arrays (172 unique genes total), and the results were examined using a variety of data mining methods. As expected, decreases in the expression of genes regulating pluripotent stem cell fate preceded subsequent increases in morphogen expression associated with differentiation. Pathway analysis generated solely from ECM and growth factor gene expression highlighted morphogenic cell processes within the embryoid bodies, such as cell
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