有哪些信誉好的足球投注网站frequent epigenetic silencing of the folate-metabolising gene cystathionine-beta-synthase in gastrointestinal cancer频繁folate-metabolising基因的表观遗传沉默cystathionine-beta-synthase在胃肠道癌症.pdfVIP
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frequent epigenetic silencing of the folate-metabolising gene cystathionine-beta-synthase in gastrointestinal cancer频繁folate-metabolising基因的表观遗传沉默cystathionine-beta-synthase在胃肠道癌症
Frequent Epigenetic Silencing of the Folate-Metabolising Gene Cystathionine-Beta-Synthase in Gastrointestinal Cancer 1. 2. 1 3 3 4 4 4 Hong Zhao , Qinshan Li , Jian Wang , Xianwei Su , Ka Man Ng , Tian Qiu , Ling Shan , Yun Ling , 2 1 4 Linfang Wang , Jianqiang Cai *, Jianming Ying * 1 Department of Abdominal Surgical Oncology, Cancer Hospital, Peking Union Medical College Chinese Academy of Medical Sciences, Beijing, China, 2 National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College Chinese Academy of Medical Sciences, Beijing, China, 3 Cancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Oncology in South China, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, 4 Department of Pathology, Cancer Hospital, Peking Union Medical College Chinese Academy of Medical Sciences, Beijing, China Abstract Background: Both gastric and colorectal cancers (CRC) are the most frequently occurring malignancies worldwide with the overall survival of these patients remains unsatisfied. Identification of tumor suppressor genes (TSG) silenced by promoter CpG methylation uncovers mechanisms of tumorigenesis and identifies new epigenetic biomarkers for early cancer detection and prognosis assessment. Cystathionine-beta-synthase (CBS) functions in the folate metabolism pathway, which is intricately linked to methylation of genomic DNA. Dysregulation of DNA methylation contributes substantially to cancer development. Methodology/Principal Find
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