有哪些信誉好的足球投注网站gene responses to oxygen availability in kluyveromyces lactis an insight on the evolution of the oxygen-responding system in yeast基因反应氧的可用性在克鲁维酵母菌属lactis进化上的洞察力oxygen-responding系统的酵母.pdfVIP
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gene responses to oxygen availability in kluyveromyces lactis an insight on the evolution of the oxygen-responding system in yeast基因反应氧的可用性在克鲁维酵母菌属lactis进化上的洞察力oxygen-responding系统的酵母
Gene Responses to Oxygen Availability in Kluyveromyces lactis: an Insight on the Evolution of the Oxygen-Responding System in Yeast 1,4. 2,5. 3 1 4 4 Zi-An Fang , Guang-Hui Wang , Ai-Lian Chen , You-Fang Li , Jian-Ping Liu , Yu-Yang Li , Monique 1 1 Bolotin-Fukuhara , Wei-Guo Bao * ´ ´ ´ 1 Universite Paris Sud-11, CNRS UMR 8621, Institut de Genetique et Microbiologie, Orsay, France, 2 School of Mathematics, Shandong University, Jinan, Shandong, China, 3 Department of Mathematics, Fuzhou University, Fuzhou, Fujian, China, 4 Institute of Genetics, State Key Laboratory of Genetic Engineering, School of Life Sciences, ´ ´ ` ˆ Fudan University, Shanghai, China, 5 Laboratoire Mathematiques Appliquees aux Systemes, Ecole Centrale Paris, Chatenay-Malabry, France Abstract The whole-genome duplication (WGD) may provide a basis for the emergence of the very characteristic life style of Saccharomyces cerevisiae—its fermentation-oriented physiology and its capacity of growing in anaerobiosis. Indeed, we found an over-representation of oxygen-responding genes in the ohnologs of S. cerevisiae. Many of these duplicated genes are present as aerobic/hypoxic(anaerobic) pairs and form a specialized system responding to changing oxygen availability. HYP2/ANB1 and COX5A/COX5B are such gene pairs, and their unique orthologs in the ‘non-WGD’ Kluyveromyces lactis genome behaved like the aerobic versions of S. cerevisiae. ROX1 encodes a major oxygen-responding regulator in S. cerevisiae. Th
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