有哪些信誉好的足球投注网站gamma-secretase-dependent and -independent effects of presenilin1 on β-catenin·tcf-4 transcriptional activitygamma-secretase-dependent和独立presenilin1β-catenin·tcf-4转录活动的影响.pdfVIP
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gamma-secretase-dependent and -independent effects of presenilin1 on β-catenin·tcf-4 transcriptional activitygamma-secretase-dependent和独立presenilin1β-catenin·tcf-4转录活动的影响
Gamma-Secretase-Dependent and -Independent Effects of Presenilin1 on b-Catenin?Tcf-4 Transcriptional Activity 1. 1,2. 1 1 2 Imma Raurell , Montserrat Codina , David Casagolda , Beatriz del Valle , Josep Baulida , Antonio ´ 2,3 ˜ 1 Garcıa de Herreros *, Mireia Dunach * ´ ´ ` 1 Unitat de Biofısica-CEB, Departament de Bioquımica i Biologia Molecular, Facultat Medicina, Universitat Autonoma de Barcelona, Bellaterra, Spain, 2 Programa de ` ` Recerca en Cancer, IMIM-Hospital del Mar, Barcelona, Spain, 3 Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain Abstract Presenilin1 (PS1) is a component of the c-secretase complex mutated in cases of Familial Alzheimer’s disease (FAD). PS1 is synthesized as a 50 kDa peptide subsequently processed to two 29 and 20 kDa subunits that remain associated. Processing of PS1 is inhibited by several mutations detected in FAD patients. PS1 acts as negative modulator of b-catenin?Tcf-4 transcriptional activity. In this article we show that in murine embryonic fibroblasts (MEFs) the mechanisms of action of the processed and non-processed forms of PS1 on b-catenin?Tcf-4 transcription are different. Whereas non-processed PS1 inhibits b-catenin?Tcf-4 activity through a mechanism independent of c-secretase and associated with the interaction of this protein with plakoglobin and Tcf-4, the effect of processed PS1
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